MR Image Guided Therapy in Prostate Cancer

Background: * Pilot study is designed to evaluate the safety and feasibility of thermal laser ablation of focal prostate tumors. * Prostate cancer is relatively slow growing, with doubling times for local tumors estimated at 2 to 4 years. * Some prostate cancers prove to be small, low grade, and noninvasive and they appear to pose little risk to the life or health of the host. Recent patient series suggest that 20% to 30% of men undergoing radical prostatectomy have pathologic features in the radical prostatectomy specimen consistent with an insignificant or indolent cancer which poses little threat to life or health. * We propose that patients with low volume and low grade disease can be best served with focal ablation of the visible prostate cancer without the side effects of urinary incontinence and erectile dysfunction associated with radiation therapy or radical surgery. Objectives: Primary Objective: -To determine feasibility and safety of magnetic resonance image-guided focal laser ablation of biopsy confirmed and magnetic resonance (MR) visible prostate cancer. Eligibility: * Greater than 18 years of age * Organ confined prostate cancer, observed on MR, and confirmed by Transrectal biopsy * Preoperative workup as dictated by the National Comprehensive Cancer Network (NCCN).org prostate cancer guidelines * Prostate-specific antigen (PSA) \< 15 ng or PSA density \< 0.15 ng/ml in patients with a PSA \> 15 ng Design: * Pilot study, testing feasibility, safety and tolerability of thermal ablation of focal prostate cancer * It is anticipated that 15 patients will be accrued for this study