Lead Sponsor

Karolinska University Hospital

Collaborators

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•Histologically verified squamos cell carcinoma, adenocarcinoma of the esopohagus or gastric cardia (type II)
•Tumor located in cervical oesophagus, not requiring laryngo-esophagectomy. Patients with performance status 0-1 axxording to WHO scale and with resectable tumours, as assessed at the prerandomisation evaluation
•Adequate haemotological function, defined as having WBC \> 3 x 10(9)/litre and platelets \> 100 x 10 (9)/litre.
•Adequate renal function defined as having normal serum creatinine level and/or calculated glomerular filtration rate \> 60 ml/min.
•Tumour stage: T1Ni, T2N0, T2N1, T3N0, T3N1, M1a

•Pregnancy and/or lactation. Women of childbearing ages can be included and provided that adequate contraceptive methods are used
•Patients with diabetes complications (e.g. rethinopathy, neuropathy) as well as patients with uncontrolled cardiac disease or myocard infarction within 12 months are considered unsuitable for chemoradiotherapy.
•Concomitant malignancy (\< 5 years since diagnosis) that can interfere the interpretation of study results, ongoing antitumoral treatment.
•Patients being unable tom comply with the protocol
•Tumor stage T1 N0, T4 NX or TXNXM1b

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