A Gene by Medication Interaction to the Acute Effects of Alcohol

Inclusion Criteria

• •Males and females age 21 - 45, as verified upon the presentation of a valid, government issued form of ID
• •Current DSM-IV diagnosis of alcohol dependence using the Mini International Neuropsychiatric Interview (MINI). Which is a shortened form of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders or SCID. The MINI will also be used to exclude patients with other diagnoses.
• •Participants do not meet DSM-IV criteria for any current (i.e., criteria met at any point in the past 30 days) Axis I disorder (including ADHD treated with medication), other than cocaine dependence or those listed above, that warrants treatment or would preclude safe participation in the protocol
• •Not currently take medications that are contraindicated for concurrent use with alcohol;
• •No subjects who have trouble reading the English language or visual or hearing problems that may interfere with the collection of data;
• •No recurring past history of severe hypertension, glaucoma, hyperthyroidism, circulatory disease, hepatitis, chronic liver disease, ulcer disease, seizure disorder, brain disease, cardiac disease, obstructed bowel, or other current treatment of medical conditions that could determine ineligibility;
• •Female subjects must not be breastfeeding and must not be pregnant, as indicated by a pregnancy test that will be conducted immediately prior dispensing of medication.
• •Subjects have to have normal EKGs results
• •Pulse less than 100 beats per minute
• •Participants have to weigh between 125-290; weighing between 125-195 lbs (57 - 88.5 kg)