Co-Administration of MK-4618 With Antihypertensive Agents (MK-4618-010)

Exclusion Criteria

• •Any illness that might confound the results of the study or pose a risk by participation
• •History of orthostatic hypotension (decrease in blood pressure upon standing accompanied by symptoms of lightheadedness or dizziness)
• •History of cancer, excepting certain skin or cervical cancers or cancers that were treated successfully 10 or more years prior to screening
• •Condition for which there is a warning, contraindication, or precaution against the use of extended release metoprolol (Panel A) or amlodipine (Panel B)
• •Consumes excessive amounts of alcohol or caffeine daily
• •Has multiple and/or severe allergies (including latex allergy) or has had an anaphylactic reaction or significant intolerance to drugs or food
• •Uses illicit drugs or has a history of drug abuse