The Effects of Provent® on Obstructive Sleep Apnea During Continuous Positive Airway Pressure Therapy Withdrawal

Exclusion Criteria

• •1. Previous ventilatory failure (awake resting arterial oxygen saturation \<93% or arterial PCO2 \> 6kPa).
• •2. Unstable, untreated coronary or peripheral artery disease, severe arterial hypertension (\>180/110mmHg).
• •3. Previously diagnosed with Cheyne-Stokes breathing.
• •4. Current professional driver.
• •5. Any sleep related accident.
• •6. Age \<20 or \>75 years at trial entry.
• •7. History of chronic nasal obstruction.
• •8. Mental or physical disability precluding informed consent or compliance with the protocol .
• •9. Non-feasible trial follow-up (for example, distance from follow-up centre, physical inability).