Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Mayo Clinic
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Ability and willingness to give written, informed consent to be screened for and if eligible to be enrolled in the study.
Age \> 18 years old.
Minimal or no alcohol use (\< 14 drinks/week in a man, \< 7 drinks/week in a woman. Approximately 10g of alcohol equals one drink unit. One drink unit equals 1 ounce of distilled spirit, one 12-oz beer, or one 4-oz glass of wine.
Collection of a standard of care liver biopsy that is obtained within 120 days of enrollment.
Collection of biosamples (serum, plasma, PMNC, muscle biopsy) within 90 days of enrollment.
NAFLD diagnosis based on standard clinical, imaging, and histological criteria.
You may not be if
Pregnant women.
Age \< 18 years old.
Unable to consent for study.
Patients who underwent liver transplant.
Patients on oral steroids for more than 2 weeks within 6 months of enrollment.
Patients with Diabetes Mellitus.
Clinical or histological evidence of alcoholic liver disease: Regular and excessive alcohol use within two years of enrollment: \> 14 drinks/week in a man, \>7 drinks/week in a woman.
Absence of any other liver disease: Autoimmune hepatitis, viral hepatitis, alpha-1 antitrypsin deficiency, hemochromatosis, drug induced liver injury, Wilson's disease, or cholestatic liver disease.
Known HIV.
Hepatocellular carcinoma.
History of bariatric surgery.
Clareo Health | Impact of Muscle Insulin Resistance on the Pathogenesis of Non Alcoholic Steatohepatitis
