Electrochemotherapy as a Palliative Treatment for Brain Metastases

Exclusion Criteria

• •Acute lung infection.
• •Previous bleomycin treatment with more than 200.000 IU/m2.
• •Previous allergic reaction to bleomycin.
• •Allergy towards the sedation used.
• •Pregnancy or breastfeeding. Pregnancy in fertile women is excluded by a measurement of HCG in a blood sample. Sterile or infertile women are excluded from the requirement to use anticonception. To be considered sterile or infertile, the patient must have undergone surgical sterilization (vasectomy/bilateral tubectomy, hysterectomy and bilateral ovariectomy) or be post-menopausal defined as the absence of menstruation.
• •Treatment with G-CSF (Granulocyte Colony Stimulating Factor) or other cytokines.
• •Lung diffusion capacity (DLCO) below normal. DLCO is to be performed in case of suspected (anamnestic or clinical) reduced lung function.
• •Physician's assessment that meningeal carcinomatosis (leptomeningeal disease) is a likely cause of the patient's symptoms.
• •Treatment with anticoagulants (marevan, marcumar, innohep).
• •Allergic to nickel, chrome or cobalt.
• •Participation in another clinical study with an experimental drug up to 4 weeks prior to inclusion.
• •Illnesses, medical, social or physiological, that may affect the patient's ability to understand the patient information and participate in the follow-up.
• •Other serious systemic illnesses (i.e. active infection, abnormal EKG) that the investigator finds may affect the patient's safety and/or ability to complete the study.
• •Treatment with Immunosuppressant drugs such as methotrexate and cyclosporine during the study. Treatment with prednisolone is accepted during the study.
• •Implanted pacemaker, defibrillators or hearth valve prosthetics.
• •Implanted devices such as neurostimulators, eartransplants, insulinpump, metallic tracheostomy.
• •Catheters with metal such as Port á cath, Swan Ganz, P-dialysis cath., ventriculoatrial and -peritoneal shunts, bladder cath. with thermo-measurement.
• •Metallic clips/prosthetics/magnets from surgery such as neuro- or abdominal clips, tooth- or other prosthetics.
• •Disorganised metallic material such as metal fragments in the eyes, shrapnel, gun shot injuries.