All eligible patients will receive SB injection therapy for 6 cycles (14\~21 days for each cycle). Efficacy will be evaluated every 3 cycles.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age of 18years or over
Patients who had failed more than 1 cycle of standard therapy with advanced or metastatic stage and with measurable lesions
Life expectancy \>/= 5 months
Not available to any of resectable surgery or radiotherapy
Patients with adequate organ(e.g. heart, kidney, liver)and bone marrow function, as defined by
1. Absolute neutrophil count \>/= 1.0 x 10\^9/L, Platelet count \>/= 75 x 10\^9/L
2. Total bilirubin \< 2.0 mg/dL
3. Aspartate Aminotransferase and/or Aspartate Aminotransferase \< 5 x Upper Limit Normal
4. creatinine \< 2 x Upper Limit Normal
ECOG status 0 to 2
Female volunteers admitted to the study must be using a reliable means of contraception and must have a negative blood or urine pregnancy test at least 7days ago
Patients or their legal representatives who have signed the informed consent form.
You may not be if
Have inflammatory bowel diseases
Have severe diarrhea or ileus
Previous total colectomy
Have ileostomy
Known brain or spinal cord metastases
Patients who have received chemotherapy within the previous 4 weeks
Patients who have received radiotherapy related tp colorectal cancer within 4weeks
Patients who have participated in other clinical study within the previous 4weeks
Pregnancy or lactation period
Human Immunodeficiency Virus antibody (+)
Have active infection or serious concomitant systemic disorder incompatible with the study
Clinically hypertension or diabetes mellitus not well controlled with medication
Clinically significant cardiac disease(congestive heart failure, symptomatic coronary artery disease and cardiac arrhythmias) or myocardial infarction
Presence or history of malignancy other than colorectal cancer within 5years
Have severe Neurologic or psychological disorder
Patients who have history of allergy with this investigational drug(SB injection)
Obvious cognitive or physical impairment that would prevent participation
Clareo Health | Evaluating the Safety and Efficacy of SB Injection in Patients With Advanced or Metastatic Colorectal Cancer
