A Dose-escalation Pharmacokinetic Study of Intravenous ASA404 in Adult Advanced Cancer Patients With Impaired Renal Function and Patients With Normal Renal Function

Inclusion Criteria

• •Patients having histologically-proven solid tumors, who are either refractory to standard chemotherapy;
• •Patients whom chemotherapy with an investigaional agent in combination with docetaxel, or paclitaxel + carboplatin is appropriate;
• •Creatinine clearance according to Cockcroft-Gault formula : Normal \> 80 mL/min, Mild 50-80 mL/min, Moderate 30-\<50 mL/min;
• •A minimum of 4 weeks must have elapsed since the last treatment with other cancer therapies;
• •Potassium, calcium, magnesium and phosphorus values within the normal range;
• •Body Mass Index (BMI) must be within the range of 18 and 30