A Study for Disease Profiling of Asthma and Chronic Obstructive Pulmonary Disease

Inclusion Criteria

• •Age: for Part 1, healthy: 18 and 55 years; for Part 1, asthma: 18 and 70 years; for Part 2, nonsmokers: 40 and 65 years; for Part 2, smokers: 40 and 65 years; for Part 2, chronic obstructive pulmonary disease (COPD): 40 and 65 years
• •Having mild, moderate, or severe asthma (for Part 1, asthma)
• •Clinically stable asthma and have been on their current asthma controller therapy for at least 6 weeks prior to screening (for Part 1, asthma)
• •No history of chronic respiratory disease including asthma (for Part 2, nonsmokers)
• •Be a nonsmoker for 1 year or more at initial screening visit and have 10 packs or less per year history of smoking (for all Part 1 and Pat 2, nonsmokers)
• •Be a current smoker with a current history of at least 20 pack years (for Part 2, smokers)
• •Stable COPD in the 3 months prior to screening (for Part 2, COPD)
• •Treating with Beta-adrenergic receptor agonist, anticholinergic bronchodilators, inhaled corticosteroid at stable doses for at least 4 weeks prior to screening (for Part 2, COPD)