Open-label Study of STA-9090 for Patients With Metastatic Breast Cancer

Exclusion Criteria

• •Surgery, radiotherapy, or lesion ablative procedure to the only area of measurable disease
• •Major surgery within 4 weeks prior to first dose of STA-9090
• •Poor peripheral venous access for study drug administration. Study drug administration via indwelling catheters allowed only if the catheter is made of silicone material.
• •History of severe (grade 3 or 4) allergic or hypersensitivity reactions to excipients (e.g., Polyethylene glycol \[PEG\] 300 and Polysorbate 80)
• •Baseline QTc \> 470 msec
• •Ventricular ejection fraction (EF) \<50% at baseline
• •Treatment with chronic immunosuppressants (e.g., cyclosporine following transplantation)
• •Women who are pregnant or lactating
• •Uncontrolled intercurrent illness including, but not limited to, human immunodeficiency virus (HIV)-positive subjects receiving combination antiretroviral therapy, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, ventricular arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• •Other medications, or severe acute/chronic medical or psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results in the judgment of the investigator
• •Seizure disorder or requirement for seizure medication
• •Prior treatment with an HSP90 inhibitor
• •persistent adverse events of prior therapies that are \> 1 grade 1 in severity
• •history of or current coronary artery disease, myocardial infarction, angina pectoris, angioplasty or coronary bypass surgery
• •history of or current uncontrolled dysrhythmias, or requirement for antiarrhythmic medications, or Grade 2 or greater left bundle branch block
• •New York Heart Association class II/III/IV congestive heart failure with a history of dyspnea, orthopnea, or edema that requires current treatment with angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, beta blockers or diuretics