A Study of Carboplatin and Paclitaxel With or Without MEDI-575 in Untreated, Advanced Non-Small Cell Lung Cancer

Inclusion Criteria

• •Histologically confirmed inoperable Stage IIIB or Stage IV non-small cell lung cancer according to the Seventh Edition of the American Joint Committee on Cancer (AJCC) Tumor Node Metastases (TNM) staging system (only participants with squamous cell carcinoma will be enrolled)
• •Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
• •Life expectancy of greater than or equal to (\>=) 3 months
• •Prothrombin time elevation less than or equal to (\<=) Grade 2 by National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI CTCAE) criteria (Version 4.0) is acceptable for participants on anticoagulant therapy
• •Adequate hematologic function
• •Adequate organ function
• •Suitable candidates for therapy with carboplatin/paclitaxel
• •Participants must have at least 1 lesion that is measurable using Response Evaluation Criteria for Solid Tumors
• •Participants must be willing to consent to allow collection of archived NSCLC tumor samples
• •Negative serum beta-human chorionic gonadotropin (beta-hCG) test (women of childbearing potential only)
• •Females of childbearing potential, unless surgically sterile has a sterile male partner, is premenarchal or at least 2 years postmenopausal, or practices abstinence, must use 2 effective methods of avoiding pregnancy (including oral, transdermal, or implanted contraceptives, intrauterine device, female condom with spermicide, diaphragm with spermicide, cervical cap, or use of a condom with spermicide by the sexual partner) from screening, and must agree to continue using such precautions for 90 days after the final dose of treatment; cessation of birth control after this point should be discussed with a responsible physician
• •Males, unless surgically sterile, must use 2 effective methods of birth control with a female partner and must agree to continue using such contraceptive precautions from screening through 90 days after the final dose of treatment