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Oral Steroid Treatment for Chronic Rhinosinusitis | Clinical Trials | Clareo Health

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WITHDRAWNNCT01255683

Oral Steroid Treatment for Chronic Rhinosinusitis

Despite the common use of oral steroids in the management of chronic rhinosinusitis (CRS), the natural history and efficacy of this treatment modality has not been fully elucidated. Specifically, pati...

Lead sponsor: Oregon Health and Science University•1 U.S. locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Oregon Health and Science University

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Adult ( \> 18 years of age)
•CRS defined by 2007 Adult Sinusitis Guidelines.12
•Subject must be able to complete QoL questionnaires written in English
•Previous sinus surgery including unilateral or bilateral total ethmoidectomy
•Minimum nasal blockage score on SinoNasal Outcomes Test-22 (SNOT-22) \> 3
•Severe sinonasal inflammation where the next treatment option is a 12- day oral prednisone taper
•Obstruction of the ethmoid sinus region or middle meatus eligible for revision endoscopic sinus surgery
•Lund-Kennedy endoscopy score \> 4
•Elects 12-day tapering dose of oral steroids (Prednisone) as a next treatment option

Exclusion Criteria

•Unable to complete questionnaires or clinical testing or cooperate with study evaluations in English
•Contra-indication to oral steroids
•Endoscopic sinus surgery \< 3 months of presentation
•Completed course of oral corticosteroids within the previous 3 month period
•Subjects presenting with unilateral chronic rhinosinusitis
•Pregnancy or possibility to become pregnant during the study

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: April 22, 2015Terms

Trial snapshot

StatusWITHDRAWN

Phase—

Enrollment—

Start dateDec 2010

Last updatedApr 22, 2015

Condition

Chronic Rhinosinusitis

Locations shown

Oregon Health & Science University

Portland, Oregon

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 22, 2015Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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