Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Merck Sharp & Dohme LLC
Age
21–60
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Participant has essential hypertension who is in grade 1 or 2 hypertension according to the European Society of Hypertension (ESH) as delineated in the European Society of Cardiology (ESC) 2007 guidelines, i.e. systolic blood pressure values of 140-179 and diastolic blood pressure values of 90-109 on at least 3 occasions prior to the study.
Otherwise healthy participants with grade 1 or 2 arterial hypertension who are treated with a single antihypertensive drug and meet the above blood pressure criteria may be enrolled at the discretion of the investigator
Participant is generally in good health with the exception of hypertension
Participant is a nonsmoker and/or has not used nicotine or nicotine-containing products for 6 months
You may not be if
Participant has a history of any illness that might confound the results of the study or pose and additional risk to the participant if they take part in the study
Participant has a history of stroke, chronic seizures, or major neurological disorder
Participant has a disability that can interfere with rising from a semi-recumbent position to the standing position
Participant has a personal or family history of a bleeding or clotting disorder
Participant has a history of frequent nosebleeds or recurrent or active gingivitis
Participant has a history of cancer, except 1) certain skin cancers; 2) cancer successfully treated more than 10 years prior to the study that has not recurred; or, 3) participants who are unlikely to have a recurrence during the study
Participant has a history of cardiac disease including but not limited to heart valve disease or evidence of secondary cardiac damage
Participant is categorized as class II or greater according to the New York Heart Association (NYHA) functional classification for heart failure
Participant is unable to refrain from use of prescription or non-prescription drugs or herbal remedies (such as St. John's Wort) during the study
Participant anticipates using phosphodiesterase (PDE5) inhibitors \[sildenafil (Viagra®), tadalafil (Cialis®), or vardenafil (Levitra®)\] during the study
Participant consumes excessive amounts of alcohol (more than 3 drinks per day) or caffeine (more than 6 servings a day)
Participant has had major surgery, donated or lost 1 unit of blood, or participated in another investigational within 4 weeks prior to the study
Participant has a history of multiple and/or severe allergies, or has had an anaphylactic reaction or intolerance to any drugs or food
Clareo Health | Safety, Pharmacodynamics, and Pharmacokinetics of Different Dosing Regimens of MK-8266 in Participants With Hypertension (MK-8266-008)
