Use of a Bimodal Solution for Peritoneal Dialysis

Exclusion Criteria

• •1. Scheduled Transplant in the next 1 year
• •2. Life expectancy \< 3 mo (estimated by physician)
• •3. Participating in other trial that could influence outcome of this trial
• •4. Known icodextrin allergy
• •5. Currently using non-Baxter PD solutions
• •6. Systolic blood pressure \< 90 mm Hg on more than three occasions during a seven day period, despite discontinuation of non-essential anti-hypertensives
• •1\) Unsuccessfully completed 1 week run-in phase. Defined as:
• •1. Not using bimodal solution on 7 consecutive days during the run-in
• •2. Not tolerating the increased UF anticipated with the bimodal solution. Tolerating defined as:
• •i) Blood pressure drop below 90/50 on more than three occasions during a seven day period that cannot be corrected by reducing anti-hypertensives or other simple measures ii) Intolerable feeling of fullness with the bimodal solution iii) Allergic reaction (although all patients have already been exposed to icodextrin)