Primary objective: To evaluate a strategy of Chronic Obstructive Pulmonary Disease (COPD) management to reduce the number of hospital days in patients with severe Gold III/IV COPD: a Home-Based COPD Management Program versus usual patient education and follow-up.
Secondary objectives:
* To assess the clinical outcome and the health-related quality of life,
* To assess safety,
* To evaluate medico-economic impact.
