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Surgical Sympathetic Blockade in Heart Failure | Clinical Trials | Clareo Health

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COMPLETEDPhase 1NCT01224899

Surgical Sympathetic Blockade in Heart Failure

The investigators sought to evaluate the feasibility and safety of surgical sympathetic blockade in systolic heart failure patients and secondary to assess its cardiovascular consequences.

Lead sponsor: University of Sao Paulo•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Sao Paulo

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•chronic heart failure (at least 1 month of symptoms onset)
•NYHA functional class II or III
•LV ejection fraction 40% or lower
•resting heart rate higher than 65 bpm
•either maximum beta-blocker therapy according to guidelines or no beta-blocker use for intolerance.

Exclusion Criteria

•NYHA functional class I or IV
•cardiogenic shock
•resting heart rate ≤ 65 bpm
•systolic blood pressure \< 90 mmHg
•sustained ventricular tachycardia
•eligibility to other surgical procedures
•procedure-limiting comorbidity
•presence of ICD or pacemaker
•valvar, chagasic or congenital cardiomyopathy
•age \> 70 years
•patient refusal
•contra-indication to videothoracoscopy
•decompensated thyroid disease
•atrial fibrillation or flutter
•active infection

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: October 20, 2010Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE1

Enrollment15

Start dateDec 2006

Last updatedOct 20, 2010

Condition

Systolic Heart Failure Beta-blockers Intolerance Beta-blockers Resistance

Locations shown

Heart Institute (InCor) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo, São Paulo

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 20, 2010Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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