Biological Response to Tamoxifen (TAM) in Patients With Breast Cancer Non Metastatic RH+

Inclusion Criteria

• •Adult Females (≥ 18 years), with effective contraception. The contraceptive should not use estrogen to a derivative. It must be continued during treatment with tamoxifen for at least two months after his arrest.
• •Histologically confirmed diagnosis of invasive breast cancer, previously untreated. Patients have been supported for a breast cancer may be included if a period of at least 2 years between the last systemic treatment of inclusion in the study.
• •Primary tumor hormonopositive: ER and / or PR ≥ 50% by immunohistochemistry.
• •Lack of HER2 overexpression
• •Palpable primary tumor or greater than or equal to 20 mm in diameter, measured by ultrasound
• •Patient scheduled to undergo breast cancer surgery
• •No metastases
• •Clinical Stage M0
• •Performance index ≤ 1 (OMS)
• •Neutrophils WBC \> or = 1500 / mm3, Platelets \> or = 100 000/mm3 Hemoglobin ≥10 g/dL
• •Normal liver function: bilirubin ≤ 1.5 x ULN, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 x ULN (≤ 5 x ULN if liver metastases).
• •Normal renal function (creatinine ≤ 1.5 mg / dL or creatinine clearance ≥ 60 mL / min)
• •Cardiac function (MUGA scan or ultrasound February\> 55%) and lung function, 5.2.2 Criteria related to participation in the study:
• •Patient affiliated to social security, Patient has signed and dated consent
• •1. Pregnant or Breastfeeding women
• •2. Use of St. John's Wort (herbal tea ...) within 5 days before starting treatment
• •3. Consumption of grapefruit juice in the last 5 days of starting treatment
• •4. Congenital galactosemia
• •5. Glucose and galactose malabsorption
• •6. Lactase deficiency
• •7. Co-medications that may interfere with cytochrome P450:
• •8. Ongoing Enzyme inducers:
• •* Antiepileptic drugs: carbamazepine, phenobarbital, phenytoin
• •* Antinfectieux: rifampin, rifabutin, névrirapine, griséofilvine, efavirenz
• •9. Ongoing Enzyme Inhibitors:
• •* Inhibitors of serotonin reuptake: fluoxetine, paroxetine
• •* Thioridazine. Quinidine
• •* Amiodarone
• •* Ca antagonists: diltiazem, verapamil
• •* azole antifungals ketoconazole, fluconazole, miconazole.
• •* No protease inhibitors: ritonavir, nelfinavir, amprenavir, indinavir.
• •* Macrolides: erythromycin, clarithromycin, josamycin