PALACE 3: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis

Inclusion Criteria

• •Males or females, aged ≥ 18 years at time of consent.
• •Have a diagnosis of Psoriatic Arthritis (PsA, by any criteria) of ≥ 6 months duration.
• •Meet the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria for PsA at time of screening.
• •Must have been inadequately treated by disease-modifying antirheumatic drugs (DMARDs)
• •May not have axial involvement alone
• •Concurrent Tx allowed with methotrexate, leflunomide, or sulfasalazine
• •Have ≥ 3 swollen AND ≥ 3 tender joints.
• •Males \& Females must use contraception
• •Stable dose of NSAIDs, narcotics and low dose oral corticosteroids allowed.
• •Have at least one ≥2 cm psoriasis lesion