Durolane Versus Methylprednisolone in Knee Osteoarthritis

Exclusion Criteria

• •Knee effusion
• •Contralateral knee OA
• •Clinically significant joint pain from joints other than the knee
• •Previous intra-articular steroid injection into the study knee within the last 3 months;
• •Previous intra-articular HA injection into the study knee within the last 9 months;
• •Previous allergic type reaction to a HA product, a steroid, or lidocaine/related anesthetics;
• •Treatment with analgesics other than paracetamol (acetaminophen) (including topical agents for the knee) within 5 half lives of the drug prior to the baseline visit;
• •Use of systemic glucocorticosteroids (excluding inhaled steroids) within the last 3 months;
• •Treatment with glucosamine/chondroitin sulfate initiated within the past 3 months
• •Change in physical therapy for the knee within the last three months
• •Arthroscopy or other surgical procedure in the study knee within the past 12 months;
• •Any planned arthroscopy or other surgical procedure during the study period;
• •Previous history or presence of active septic arthritis
• •Active skin disease or infection in the area of the injection site;
• •Systemic active inflammatory condition or infection
• •Bleeding diathesis or use of anticoagulants
• •Current uncontrolled diabetes mellitus;
• •Any medical condition that in the opinion of the investigator makes the subject unsuitable for inclusion
• •Pregnant or breastfeeding woman or woman of childbearing potential not practicing adequate contraception;
• •Involvement in other clinical trials