Effect of Allergen Challenge on Inflammation Induced by Toll-like Receptor Stimulation in a Nasal Model

Exclusion Criteria

• •1. Subjects with a viral URTI within 2 weeks prior to screening.
• •2. Subjects with a TNSS\> 2 at screening
• •3. Subjects with a structural nasal abnormality or nasal polyps on examination, a history of frequent nose bleeding, nasal surgery within the previous 3 months.
• •4. Subjects who are a current smoker or have a history of smoking within the previous 3 months.
• •5. Subjects who have used a medication that could affect responses to nasal challenge (eg corticosteroids, decongestants, anti-histamines) or any other nasally applied medication within 2 weeks prior to screening.
• •6. Subjects who have participated in any other clinical trials within the previous 3 months.
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