Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Yonsei University
Age
20–50
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Adult subjects 20-50 years of age
Above 55Kg and within ±20% ideal body weight
Subjects who are in average of 130mmHg ≤ systolic blood pressure (SBP) \< 160mmHg, 80mmHg ≤ diastolic blood pressure (DBP) \< 100mmHg
Female subject who confirmed non-pregnant status and agree to comply with proper contraception.
Subjects who wrote informed consent
You may not be if
Subjects who are suspected to have acute disease
Subjects who have past history that may affect drug absorption, distribution, metabolism and elimination
Subjects who have gastrointestinal history
Subjects whose heartrate is less than 60
Subject who suspected to orthostatic hypotension
Subjects who have clinically significant allergy disease
Subject is currently participating or has participating in a study with an investigational compound or device within 30 days of signing informed consent
Administration of prescription drug within 14 days or over the counter (OTC) drug within 7 days
Subjects who have past history of drug abuse and positive in drug screening test
Subjects who donate whole blood within 60 days and platelet within 30days.
Subjects taking St John's wort or CYP inhibitor and inducer
Clareo Health | Pharmacokinetic Drug Interactions Between Single and Concomitant Administrations of Amlodipine, Losartan, and Hydrochlorothiazide in Subjects With (Pre)Hypertension
