Safety and Efficacy of Chlorthalidone + Amiloride to Elderly Patients Treatment With Arterial Hypertension

Exclusion Criteria

• •Any serious or severe clinically significant medical condition.
• •Psychiatric or neurological diseases
• •A condition that, as per Principal Investigator's opinion, may interfere with the optimal participation in the study, or that may result in special risk to the patient.
• •Participation in any other investigational study within 12 months prior to Visit 1.
• •Known medical history of allergy, hypersensitivity or intolerance to any of the formulation compounds to be used in this study
• •Routine prior use of diuretics
• •Oral anticoagulant use
• •Fast glycemia \> 150 mg/dL
• •Medical treatment, not related to study, scheduled for the clinical trial duration; except non-serious, controlled comorbidities in current medical follow-up.
• •Expected onset of additional antihypertensive drug after the study onset
• •Acute myocardial infarction within last 6 months
• •Prior decompensated coronary artery disease
• •Known thyroid, renal or liver dysfunction, at investigator's discretion
• •Obesity - body mass index (BMI) \> 33 kg/m2