Effects of Intentional Weight Loss Interventions in Chronic Kidney Disease

Exclusion Criteria

• •1. History of prior and functioning kidney transplant or on dialysis
• •2. Cardiovascular conditions including significant known coronary artery disease (recent PCI or CABG within last 6 months), uncompensated congestive heart failure and/or EF \<30%, history of stroke (within last 6 months), or uncontrolled hypertension (defined as SBP \> 180 mm Hg or DBP \> 110 mm Hg).
• •3. HbA1C \>8.0%
• •4. Hemoglobin \<10 g/dl or hematocrit \<30 (within the last 6 months)
• •5. Presence of active inflammatory disease such as AIDS, hepatitis B or C, or other active inflammatory diseases such as vasculitis
• •6. Patient being treated for malignancy (excluding basal or squamous cell carcinoma of the skin)
• •7. Patients taking anti-inflammatory medication such as NSAIDS except aspirin \< 325 mg/day over the past 30 days, or on any dose of prednisone therapy
• •8. On other study drug protocols
• •9. Patient on beta-blocker therapy - only for diet/exercise group
• •10. Patients can be on Angiotensin converting enzyme inhibitors/Angiotensin receptor blocker therapy that was started at least 3 months prior to the enrollment. New Angiotensin converting enzyme inhibitors/Angiotensin receptor blocker therapy initiation will not be allowed during the study period