Efficacy Trial of the Implantation of Mouse Renal Adenocarcinoma Macrobeads in Subjects With Castration-Resistant Prostate Cancer Resistant to Taxanes (Docetaxel, Cabazitaxel) and Evidence of Disease Progression on Androgen-axis Inhibition and/or Immunotherapy in the Form of Sipuleucel-T

Exclusion Criteria

• •Any condition presenting an unacceptably high anesthetic or surgical risk
• •HIV positive
• •Cognitive impairment such as to preclude informed consent
• •Other surgical treatment, chemotherapy and radiation within four weeks of baseline
• •Inadequate hematologic, coagulation (INR \>3), hepatic, renal function
• •Hepatic blood flow abnormalities and/or large-volume ascites
• •Concurrent cancer of any other type except skin cancer (excluding melanoma)
• •History of allergic reactions to mouse antigens
• •Active infection, congestive heart failure, unstable angina, serious cardiac arrhythmias, psychiatric illness, difficult social situations not permitting reliable participation, active bleeding