Resveratrol and Midazolam Metabolism

Inclusion Criteria

• •18 to 50 years old.
• •Body mass index between 18 and 30 kg/m2.
• •Good health without a self-reported history of liver, kidney, gastrointestinal or heart disease
• •Women use measures to avoid conception during the study period (e.g. oral contraceptives, intrauterine devices \[IUDs\], and condoms)
• •Subjects must agree not to take any known substrates, inhibitors, inducers or activators of CYP3A4 at least 2 weeks before study start and for the entire duration of the study.
• •Avoid ingesting grapefruit, grapefruit juice or other grapefruit juice containing products, and any herbal-based nutrient supplement or prescribed medications during the same period of time.
• •Willing to fast overnight before the study days.
• •Willing to abstain from alcohol-containing beverages 24 hours before and during the study visits, and willing to abstain from grapefruit, cranberry, blueberry products, peanuts and peanut butter, grape and grape products, and red wine at least one week prior to and during the study.