Lead Sponsor

Intermountain Health Care, Inc.

Age

18 - 45 years

Sex

FEMALE

Healthy Volunteers

No

•Women delivered \>37 weeks gestation in the Intermountain Healthcare Urban Central Region within the last 18 months to ascertain those at risk for GDM in their next pregnancy because of:
•A history of gestational diabetes in their immediately prior pregnancy
•A family history (i.e. type 2 diabetes in a first or second degree relative) of type 2 diabetes
•Delivery of an infant \> 4000 gms.
•B.M.I. \> 30 six months postpartum
•Hemoglobin A1C \> 6.1% six months postpartum

•History of \>1 miscarriage or fetal demise
•No contraindication to metformin (prior metformin intolerance, metabolic acidosis, GI disease)
•Hypertension (BP \>135/85)
•No other endocrine, metabolic, renal, or autommune medical disorders
•Prior preterm birth
•Prior delivery complicated by shoulder dystocia
•Prior delivery complicated by neonatal palsy
•Multifetal pregnancy, including first-trimester embryonic demise of one or more
•Uterine malformations
•Illicit drug or alcohol abuse during current pregnancy
•Intent to deliver elsewhere
•Non-availability for prospective specimen/data collection

Related studies

NCT07517406 · Gestational Diabetes Mellitus (GDM), Pregnancy Complications, and more

NCT06988306 · Diabetes Mellitus, Gestational Diabetes Mellitus (GDM)

NCT06548828 · Gestational Diabetes Mellitus in Pregnancy, Glucose Intolerance During Pregnancy, and more

NCT06648174 · Gestational Diabetes Mellitus, Continuous Glucose Monitoring

NCT06948825 · Weight Loss, Gestational Diabetes Mellitus in Pregnancy, and more

Early Intervention for Gestational Diabetes