Characterization of the Kinetics of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and in Subjects With Type 2 Diabetes Mellitus (T2DM)

Inclusion Criteria

• •Diagnosis of T2DM
• •Must be on one of the following therapies: diet therapy alone, diet plus a sulfonylurea, diet plus metformin, or diet plus sulfonylurea plus metformin
• •Subjects taking metformin, and/or sulfonylurea must be on a stable dose for at least 2 months prior to study drug administration
• •Must have a fasting plasma glucose concentration ≤ 200 mg/dl, and HbA1C ≤ 10%
• •Healthy subjects (as determined by no clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations)
• •Subjects with (eGFR ≥ 60 and ≤ 160 mL/min/1.73m² and urinary albumin excretion \< 300 mg/g creatinine)
• •Body Mass Index (BMI) of 18 to 38 kg/m²
• •Men and women, ages 18 to 65 years, inclusive