A Blinded, Dose Ascending Study to Assess the Pharmacokinetics, Safety and Tollerability of Repeat Inhaled Doses of Nebulised GW870086X in Healthy Adult Male Volunteers.

Exclusion Criteria

• •A subject will not be eligible for inclusion in this study if any of the following criteria apply:
• •1. A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening.
• •2. Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
• •3. A positive pre-study drug/alcohol screen.
• •4. A positive test for HIV antibody.
• •5. History of regular alcohol consumption within 6 months of the study defined as:
• •For EU sites: an average weekly intake of \>21 units for males. One unit is equivalent to 8 g of alcohol: a half-pint (\~240 ml) of beer, 1 glass (125 ml) of wine or 1 (25 ml) measure of spirits.
• •6. The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
• •7. Exposure to more than four new chemical entities within 12 months prior to the first dosing day.
• •8. Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication, unless in the opinion of the Investigator and GSK Medical Monitor the medication will not interfere with the study procedures or compromise subject safety.
• •9. History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation.
• •10. Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period.
• •11. Unwillingness or inability to follow the procedures outlined in the protocol.
• •12. Subject is mentally or legally incapacitated.
• •13. Subjects who are kept due to regulatory or juridical order in an institution.
• •14. Subjects who are in military service.
• •15. History of sensitivity to heparin or heparin-induced thrombocytopenia.
• •16. Subjects who have asthma or a history of asthma.
• •17. Subject is a smoker or an ex-smoker with a smoking history of \> 5 pack years (Pack years = (cigarettes per day smoked/20) x number of years smoked)).
• •18. Consumption of red wine, seville oranges, grapefruit or grapefruit juice and/or pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices from 7 days prior to the first dose of study medication.