Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache

Exclusion Criteria

• •Patients with a history of severe cardiovascular disease, diabetes, asthma, COPD, hypertension, or a history of bleeding, particularly in the gastrointestinal tract
• •Patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or allergic-type reactions after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors
• •Pregnant or lactating patients. Sexually active women of childbearing age will be included only if using birth control
• •Severe hepatic dysfunction
• •Estimated renal creatinine clearance \<30 ml/min
• •History of peptic ulcer, erosive gastritis, esophagitis or inflammatory bowel disease
• •Congestive heart failure
• •Patients with hypertension whose blood pressure is persistently elevated above 140/90mmHg and has not been adequately controlled Established ischaemic heart disease, peripheral arterial disease, and/or cerebrovascular disease
• •Cancer or any other malignant disease
• •History of medication overuse. Overuse of analgesics or antimigraine drugs according to the IHS criteria (chapter 8)