Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis

Inclusion Criteria

• •Children aged 3 through 12 years of age at time of enrollment diagnosed with Cystic Fibrosis and pancreatic insufficiency
• •Enrolled in the CFF registry study or Toronto CF Registry
• •CF defined as sweat chloride of \>60 mEq/L on one occasion (using the value in the CF registry) or two disease-causing mutations of CFTR with evidence of end organ involvement.
• •Pancreatic insufficient defined as one of the following:
• •* CFTR Mutation associated with pancreatic insufficiency
• •* Fecal elastase \<100 mcg/gm (at any time)
• •* 72 hour fecal fat with coefficient of fat absorption \<85% (at any time)