Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure

Exclusion Criteria

• •Heart failure due to primary valvular heart disease
• •Presence of moderate to severe mitral insufficiency due to intrinsic mitral valve disease
• •Hypertrophic obstructive or restrictive or post partum cardiomyopathy
• •Exercise capacity limited by class IV angina pectoris
• •Acute MI, cardiac surgery, PCI, AICD, or CRT within 3 months of randomization
• •Active myocarditis
• •Planned AICD or CRT
• •Presence of a left-ventricular assist device
• •Transplanted heart or expected to receive a transplanted heart within the next 6 months
• •Pregnancy
• •Current use of ASV or CPAP or mandibular advancement device for treatment of sleep apnea or treated with any investigational therapy during the last 4 weeks (including approved therapies being used in unapproved indications)
• •A clinical history that would interfere with the objectives of this study or that would in the investigator's opinion preclude safe conclusion of the study
• •Any other medical, social, or geographical factor, which would make it unlikely that the patient will comply with the study procedures (e.g. alcohol abuse, lack of permanent residence, severe depression, disorientation, distant location, or history of non-compliance)
• •Any contraindication to ASV therapy as detailed in the device provider manual