Mean sitDBP≥110mmHg or sitSBP≥180

Secondary hypertension or suspected secondary hypertension

Uncontrolled diabetes

Severe heart disease or severe cerebrovascular disease

clinically significant hematological test results, renal disease (serum creatinine) or liver disease (ALT or AST)

History of malignant disease

Autoimmune disease

Women with a positive pregnancy test result, breast feeding or intention of pregnancy during the trial

Efficacy and Safety of Lercanidipine and Valsartan in Patients With Essential Hypertension