Lead Sponsor

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Age

0 - 80 years

Sex

ALL

Healthy Volunteers

No

•Elderly patients \< 80 years old.
•COPD (ERS/ATS (FEV1 \< 80%, FEV1/FVC \< 70%, TLC \> 80%)).
•Oxygen therapy indication (PaO2 \< 55 mmHg or 55-59 associated to pulmonary arterial hypertension, chronic Cor Pulmonale, Chronic Heart failure, arrhythmias or polyglobulia).
•PaCO2 \> 50 mm Hg.
•Clinically stable at least prior to one month.
•Hypercapnic response: increasing PaCO2 \> 10 mmHg at 7 a.m after all night with oxygen compared with PaCO2 when awake and without oxygen therapy.

•Active smoker.
•Bronchiectasis or tuberculous after-effects.
•Chronic respiratory failure secondary to thorax cage or neuromuscular diseases.
•BMI \> 35 kg/m2
•OSAS.
•Locomotor system problems that disable 6 minutes walking test execution.
•Patients with tracheostomy.
•Other serious comorbidity (i.e chronic heart failure functional class \> II NYHA, cancer or chronic renal failure that requires dialysis.