Impact of Hot Flashes on Sleep and Mood Disturbance

Exclusion Criteria

• •Pregnancy or currently breastfeeding
• •Hot flushes
• •Mid-luteal phase progesterone \<3ng/mL
• •Clinically significant abnormalities in screening blood tests
• •BMI \> 35 kg/m2
• •Previously diagnosed osteoporosis or osteopenia
• •Clinically significant depressive symptoms
• •Psychiatric illness
• •Sleep apnea or periodic limb movement of sleep (PLMS)
• •Contraindication, hypersensitivity, or previous allergic reaction to GnRH agonists
• •Current or recent use of centrally active medications
• •Current or recent use of systemic hormone medications
• •Night shift workers
• •Current use of over-the-counter (OTC) medications that may affect hot flashes, sleep, or mood
• •Abnormal vaginal bleeding
• •History of any medical diseases that may put subject at risk when treated with study medication.