Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Mclean Hospital
With
GlaxoSmithKline
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Male or female (not pregnant or nursing)
Age 18-65; with a focus on age 30-40 years
Episodic migraine (experience migraine headache \<14 days out of the month), with focus on left-sided pain
Currently taking Treximet routinely for migraine treatment
No significant medical history (No illnesses such as seizure disorder, diabetes, alcoholism, cardiac disease including coronary artery disease, psychiatric problems; drug addiction, respiratory problems, liver disease, etc.)
No significant medication history, except for migraine
Weight, \<285 pounds
Not claustrophobic
No contraindication to taking triptans
You may not be if
Age \<18 or \> 65
Significant medical problems (aside from pain before, during and after migraine episodes)
Positive drug of abuse screen (excluding medications currently prescribed for their clinical condition, e.g. opioids, benzodiazepines, etc.)
Use of opioid medications
Claustrophobia
History of dermatological hypersensitivity in the facial area
Pregnancy
Sensory loss detected on Quantitative Sensory Testing at screening
Significant alcohol history (ingestion of 5 or more glasses (\> 40 oz) of alcohol per week)
Metal implants of any type (including dental bridges, crowns, retainers, orthodontic devices e.g. braces, etc.)
Tattoos containing metallic ink on the neck, shoulders, upper arm and head (which could become heated up in the scanner, and potentially cause blistering or burning)
Cardiac pacemakers
Aneurysm clips and other vascular stents, filters, clips or other devices
Prosthetic heart valves
Other prostheses
Neuro-stimulator devices
Implanted infusion pumps
Cochlear (ear) implants
Ocular (eye) implants or known metal fragments in eyes
Exposure to shrapnel or metal filings (sheet metal workers, welders, and others)
