Treximet Migraine Brain Imaging Research Study

Exclusion Criteria

• •Age \<18 or \> 65
• •Significant medical problems (aside from pain before, during and after migraine episodes)
• •Positive drug of abuse screen (excluding medications currently prescribed for their clinical condition, e.g. opioids, benzodiazepines, etc.)
• •Use of opioid medications
• •Claustrophobia
• •History of dermatological hypersensitivity in the facial area
• •Pregnancy
• •Sensory loss detected on Quantitative Sensory Testing at screening
• •Significant alcohol history (ingestion of 5 or more glasses (\> 40 oz) of alcohol per week)
• •Metal implants of any type (including dental bridges, crowns, retainers, orthodontic devices e.g. braces, etc.)
• •Tattoos containing metallic ink on the neck, shoulders, upper arm and head (which could become heated up in the scanner, and potentially cause blistering or burning)
• •Cardiac pacemakers
• •Aneurysm clips and other vascular stents, filters, clips or other devices
• •Prosthetic heart valves
• •Other prostheses
• •Neuro-stimulator devices
• •Implanted infusion pumps
• •Cochlear (ear) implants
• •Ocular (eye) implants or known metal fragments in eyes
• •Exposure to shrapnel or metal filings (sheet metal workers, welders, and others)
• •Other metallic surgical hardware in vital areas
• •Any known allergic side effects to Treximet
• •Use of any of the following medications:
• •Monoamine Oxidase A- Inhibitors (Azilect, Eldepryl, Marplan, Nardil, Parnate, Zelapar)
• •SSRI's: citalopram/ Celexa, Lepraxo, paroxetine/ Paxil, fluoxetine/ Prozac, Sarafem, Symbyax, Sertraline/ Zoloft, Fluvoxamine/ Luvox
• •SNRI's: duloxetine/ Cymbalta, venlafaxine/ Effexor
• •Triptans: sumatriptan/ Imitrex, naratriptan/ Amerge, zolmitriptan/ Zomig, rizatriptan/ Maxalt, eletriptan/ Relpax, almotriptan/ Axert
• •Ergotamine type medicines: Bellergal, Cafergot, Ergomar, Wiraine, Migranal/ DHE45, Sansert