Hyperbaric Oxygen Therapy in Chronic Traumatic Brain Injury or Post-Traumatic Stress Disorder

Exclusion Criteria

• •1. Pulmonary disease that precludes HBOT (e.g., asthma unresponsive to medication, bullous emphysema).
• •2. Unstable medical conditions that are contraindicated in HBOT (e.g. severe congestive heart failure or heart failure requiring hospital emergency evaluation or admission in the previous year).
• •3. Severe confinement anxiety (claustrophobia; e.g., patients who require anesthesia conscious sedation for MRI or who cannot go in elevators).
• •4. Pregnancy.
• •5. Other pre-TBI neurological diagnoses.(seizure disorders, multiple sclerosis, Parkinson's, Lyme, etc.)
• •6. Participation in another experimental trial with active intervention.
• •7. High probability of inability to complete the experimental protocol (e.g. terminal condition).
• •8. Past or current history of mental retardation unless diagnosed post TBI (baseline IQ ≤ 70).
• •9. Pre- or post-TBI history of systemic illness with impact on central nervous system. (Principal Investigator in consultation with study sponsor Medical Officer will make the ultimate decision).
• •10. Any pre-existing chronic infection not related to battlefield injuries or government service.