Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Health Research Institutes, Taiwan
Age
18–60
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
DSM-IV diagnosed schizophrenic patients;
Age between 18 and 60;
Before treatment with clozapine, documented treatment failure of two antipsychotics for an adequate duration of 6 weeks and in a sufficient dose of 600 mg/day of chlorpromazine equivalents;
Documented failure to show a satisfactory clinical response to an adequate clozapine treatment, defined as at least clozapine 300 mg/day for 3 months or a plasma drug level of 350ng/ml;
At least moderately ill, defined as with a Clinical Global Impression (CGI) greater than 4 or PANSS total score greater than 75;
Persistent positive psychotic symptoms, with rating scores of moderate or worse on at least two of four positive symptom items (delusion, conceptual disorganization, hallucinatory behavior, and suspiciousness/persecution) on Positive and Negative Syndrome Scale (PANSS);
You may not be if
Patients with concomitant treatment with lithium, anti-convulsants, antidepressants and other antipsychotic medication ;
Patients with underlying severe medical illness, such as cardiovascular disease, cerebrovascular disease, bone marrow suppression or epilepsy;
Patients with comorbid diagnosis of substance dependence;
