Aldosterone Blockade in Chronic Kidney Disease: Influence on Arterial Stiffness and Kidney Function

Exclusion Criteria

• •p-potassium is \> 5.0 mM
• •allergy to contents
• •treated with spironolactone
• •treated with potent inhibitors of CYP3A4 (see SPC for details)
• •treated with lithium, ciclosporin, tacrolimus, prednisolone, or other immunosuppressing drug
• •inborn errors of metabolism (see SPC for details)
• •pregnancy or lactation
• •fertile woman, not using safe contraception devices
• •dementia or other psychiatric disorder, making understanding of the study conditions impossible
• •other severe, chronic illness besides CKD, including liver insufficiency, according to investigators' judgement
• •vascular surgery including stenting or graft implantation on a. brachialis, aorta or the carotid arteries
• •systolic BP \> 200 mmHg
• •immeasurable pulse amplitude