RituxiMab INDuction in Renal Transplantation

Exclusion Criteria

• •Previous other organ transplants lost through acute rejection
• •Patients undergoing antibody incompatible transplantation
• •Patients with other organ transplants
• •Patients previously treated with cyclophosphamide, ATG, OKT3 or rituximab
• •Patients with white cell count below 4.0x10\^9/L.
• •Patients with platelet count below 100x10\^9/L
• •Patients who are treated with drugs that are strong inhibitors or inducers of cytochrome P450, or treated with terfenadine, astemizole, cisapride or lovastatin
• •Patients who have been involved in any other investigational trial or non protocol immunosuppressive regimen in the previous 90 days prior to transplant
• •Pregnant or breastfeeding women
• •Patients with a documented history of malignancy and its origins and treatment in the last five years. (Localised basal cell carcinoma of the skin is permitted)
• •Patients known to be HIV, Hepatitis B surface antigen or Hepatitis C antibody positive
• •Patients who in the opinion of the Investigator would not be a suitable candidate for study participation
• •Women of child bearing potential not willing to take adequate contraception