Study of NMS-1116354 in Advanced/Metastatic Solid Tumors

Exclusion Criteria

• •1. Current enrollment in another therapeutic clinical trial
• •2. Known brain metastases
• •3. Currently active second malignancy
• •4. Major surgery within 4 weeks prior to treatment
• •5. Any of the following in the past 6 months: myocardial infarction, unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein thrombosis
• •6. Pregnancy or breast-feeding women
• •7. Known active infections
• •8. Gastrointestinal disease or other malabsorption syndromes that would impact on drug absorption
• •9. Adrenal insufficiency
• •10. Other severe acute or chronic medical or psychiatric condition that could compromise protocol objectives