Adenosine 2A Agonist Lexiscan in Children and Adults With Sickle Cell Disease

Exclusion Criteria

• •Participants with a current physician diagnosis of asthma (within last 12 months), require continuous supplemental oxygen, or predicted or current use of some asthma medications.
• •Participants with second- or third-degree AV block or sinus node dysfunction
• •Have a history of bleeding diathesis
• •Have a history of clinically overt stroke
• •Have a history of severe hypertension not adequately controlled with anti-hypertensive medications
• •Participants who are receiving chronic anti-coagulation or anti-platelet therapy
• •Participants with a history of metastatic cancer
• •Participants who have had a hospitalization or emergency room visit for any reason in the past 2 weeks
• •Participants may not be receiving any other study agents or have received a study agent in the past 30 days
• •Uncontrolled intercurrent illness
• •Pregnant or breastfeeding women
• •Participants with HIV
• •Participants who have previously enrolled and received the investigational agent as part of this study
• •Participants who are taking medications that may interact with the investigational agent
• •Participants with a current physician diagnosis of asthma (within last 12 months), require continuous supplemental oxygen, or predicted or current use of some asthma medications.
• •Participants with second- or third-degree AV block or sinus node dysfunction
• •Have a history of bleeding diathesis
• •Have a history of clinically overt stroke
• •Have a history of severe hypertension not adequately controlled with anti-hypertensive medications
• •Participants who are receiving chronic anti-coagulation or anti-platelet therapy
• •Participants with a history of metastatic cancer
• •Participants may not be receiving any other study agents or have received a study agent in the past 30 days
• •Participants with a current physician diagnosis of asthma (within last 12 months), require continuous supplemental oxygen, or predicted or current use of some asthma medications.
• •Participants with second- or third-degree AV block or sinus node dysfunction
• •Have a history of bleeding diathesis
• •Have a history of clinically overt stroke
• •Have a history of hypertension not adequately controlled with anti-hypertensive medications
• •Participants who are receiving chronic anti-coagulation or anti-platelet therapy
• •Participants with a history of metastatic cancer
• •Participants may not be receiving any other study agents or have received a study agent in the past 30 days
• •Participants with HIV
• •Participants who have previously enrolled and received the investigational agent as part of this study
• •Participants who are taking medications that may interact with the investigational agent