Lead Sponsor

Guillermo Umpierrez

Age

18 - 45 years

Sex

FEMALE

Healthy Volunteers

Yes

•Blacks and Hispanic
•women between 18-45 years of age;
•2\) overweight and obese (BMI \> 25 kg/m2),
•3\) have a sedentary lifestyle (\<30 minutes/day of moderate physical activity), and
•4\) prenatal care established at less than 20 weeks of gestation,
•5\) with a singleton pregnancy.

•Women with 1) age \< 18 or \> 45 years,
•2\) \> 20 weeks gestation,
•3\) history of diagnosis of type 2 diabetes, hypertension, cardiovascular disease, chronic renal disease, and active liver disease (AST \> 3 ULN),
•4\) anemia (hemoglobin \< 10 g, hematocrit \< 32%);
•5\) current medications which adversely influence glucose tolerance (corticosteroids),
•6\) multiple pregnancy,
•7\) women not planning to continue pregnancy to term, 7) contraindications to participate in regular physical activity,
•8\) patients with mental conditions rendering them unable to understand the nature, scope, and possible consequences of the study