A Trial of Telmisartan Prevention of Cardiovascular Disease

Inclusion Criteria

• •1. Outpatients
• •2. Age: ≥ 40 to \< 80
• •3. Hypertension: Systolic blood pressure of ≥ 140 mmHg or diastolic blood pressure of ≥ 90 mmHg in the two latest measurements of casual blood pressure (in the sitting position) regardless of treated or untreated condition, or systolic blood pressure of \< 140 mmHg and diastolic blood pressure of \< 90 mmHg that require antihypertensive treatment.
• •Assessment of hypertension: Blood pressure will be measured at least twice at an interval of 1 to 2 minutes. If the measured values obtained are substantially different, additional measurements will be performed and the average of two stable measurements will be used for assessment.
• •4. Patients who have given consent to participate in the present study.
• •Cardiovascular risks:
• •1. Diabetes mellitus; Type 2 diabetes mellitus
• •2. Kidney; Serum creatinine: 1.2 mg/dL - \< 2.0 mg/dL for males, 1.0 mg/dL - \< 2.0 mg/dL for females Proteinuria: qualitative value of ≥ +1 (quantitative value: proteinuria with the value of ≥ 0.3 g/g・Cr in casual urine when adjusted with urine creatinine) CKD stage 3 or higher (GFR \< 60 mL/min/1.73 m2)
• •3. Heart; Previous myocardial infarction noted more than 6 months before obtaining the informed consent Diagnosis of angina pectoris Diagnosis of heart failure (NYHA I or II class) Diagnosis of left ventricular hypertrophy (left ventricular posterior wall of ≥ 12 mm evidenced by echocardiography performed prior to obtaining the informed consent, or Sv1+Rv5 of ≥ 35 mm noted as ECG finding) Diagnosis of transient or persisting atrial fibrillation
• •4. Brain; Previous cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage or transient cerebral ischemic attack noted more than 6 months before obtaining the informed consent
• •5. Peripheral arterial diseases; Previous lower-limb bypass surgery or angioplasty performed more than 6 months before obtaining the informed consent Ankle-brachial pressure index of \< 0.9 or intermittent claudication