Bioequivalence Study of 2.5-mg Saxagliptin and 500-mg Glucophage in Tablets and a Fixed-dose Combination Tablet in Healthy Participants

Exclusion Criteria

• •Any significant acute or chronic medical illness
• •Current or recent (within 3 months) gastrointestinal disease
• •Any major surgery within 4 weeks of study drug administration
• •History of allergy to DPP-4 inhibitors or related compounds
• •History of allergy or intolerance to metformin or other similar acting agents
• •Previous exposure to saxagliptin
• •Exposure to metformin within 3 months pervious to study drug administration
• •Estimated creatinine clearance of \<80 mL/min using the Cockcroft Gault formula