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UNKNOWNPhase 3NCT01061320

Efficacy of Alpha Tocopherol for Prevention of Contrast-induced Nephropathy in Chronic Kidney Disease (CKD) Patients

The purpose of this study is to demonstrate the efficacy of alpha tocopherol for prevention contrast-induced nephropathy in CKD patients undergoing elective coronary procedures.

Lead sponsor: Thammasat University•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Thammasat University

Contrast-induced nephropathy (CIN) increases the likelihood of patient morbidity and mortality following coronary procedures. Contrast agents cause an acute deterioration in renal function via the generation of reactive oxygen species. Vitamin E (alpha tocopherol)was demonstrated to be anti-oxidant and anti-inflammation. The present study was designed to evaluate the administration of antioxidant vitamin E (alpha tocopherol) as a means of preventing CIN in these patients.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•serum creatinine levels \> 1.2 mg/dL and baseline creatinine clearance levels \< 60 mL/min (as measured in their most recent sample,drawn within 2 months prior to the beginning of the study)

Exclusion Criteria

•patients with acute kidney injury
•end stage renal disease (requiring dialysis)
•unstable renal function (as evidenced by a change in serum creatinine of \> 0.5 mg/dL, or \> 25%, within 14 days prior to the study)
•allergy to any of the contrast agents
•mechanical ventilation
•suffered from congestive heart failure, cardiogenic shock or emergent angiography.
•receiving NAC, mannitol, diuretics, theophylline, dopamine, vitamin E or contrast agents within 14 days before the study

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 3, 2010Terms

Trial snapshot

StatusUNKNOWN

PhasePHASE3

Enrollment200

Start dateJan 2010

Last updatedFeb 3, 2010

Condition

Contrast Induced Nephropathy

Locations shown

Adis Tasanarong

Khlong Luang, Pathumtani

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 3, 2010Data synced to Clareo: July 13, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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