Lead Sponsor

Amarin Pharma Inc.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Men and women, ages \>18
•Fasting triglyceride ≥500 mg/dL and ≤2000 mg/dL
•Provide written informed consent and authorization for protected health information disclosure

•Women who are pregnant or lactating, or planning to become pregnant
•Use of non-statin lipid-altering drugs which cannot be stopped including fibrates, niacin, fish oil and other products containing omega-3 fatty acids or other dietary supplements with potential lipid-altering effects
•History of pancreatitis
•History of bariatric surgery or currently on weight loss drugs
•Uncontrolled hypertension (BP \> 160/100)
•HIV infection or on treatment with HIV-protease inhibitors, cyclophosphamide,or isotretinoin
•Consumption of more than 2 alcoholic beverages per day
•History of cancers (except if been disease free for \>5 years OR history was basal or squamous cell skin cancer)
•Participation in another clinical trial involving an investigational agent in the last 30 days
•Other parameters will be assessed at the study center to ensure eligibility for this study.