Lead Sponsor

Centre Georges Francois Leclerc

Collaborators

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

No

•Histopathologically proven diagnosis of glioblastoma (WHO grade IV astrocytoma)
•Diagnosis must be obtained by a stereotactic or surgical biopsy
•Age between 18 and 70
•Total or partial surgical resection deemed as not possible by a neurosurgeon
•OMS performance status 0 or 1
•Adequate blood function : absolute neutrophil count \> 1.5 x 109/L, platelets count \> 100 x 109/L platelets;
•Adequate liver function: bilirubin \< 1.5 ULN (upper limit of normal), ALT and AST \< 3 ULN,
•Adequate renal function: creatinine \< 1.5 ULN
•Patient must have been informed and must have signed the specific informed consent form.

•other malignancy histology
•resection of the brain tumor complete on MRI exploration
•patient unable to give informed consent
•patient presenting counter-indication to MRI exploration
•patient must not have received neither radiotherapy nor chemotherapy for that affection
•concomitant malignancy
•patient already enrolled in another biomedical study with an experimental molecule
•pregnant, nursing woman, or without contraception
•private individuals of freedom or under tutelage (including legal guardianship)
•psychiatric, behavioural disorders or geographical situation precluding the administration or follow-up of the protocol (including claustrophobia)

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