Preoperative Radiation Therapy for High Risk Prostate Cancer

Exclusion Criteria

• •prior pelvic radiation therapy, chemotherapy, or androgen deprivation,
• •prior invasive malignancy, except non- melanomatous skin cancer, carcinoma in-situ of the bladder or head and neck region, unless disease free for a minimum of 5 years.
• •Metastatic disease as demonstrated by bone scan, CT scan or MRI of the pelvis, or chest x-ray.
• •Pathologically documented positive pelvic lymph nodes. If Pre-operative CT scan or MRI (ordered at the discretion of the treating physicians) demonstrates lymph nodes which are suspicious for involvement, then biopsy must be undertaken and nodes proven negative before patient can enroll on this trial.
• •Declared high-risk for anesthesia by attending anesthesiologist, cardiologist, or other physician.
• •History of prior pelvic radiation therapy.
• •History of androgen deprivation therapy or chemotherapy.