Age

18–80

Sex

ALL

Healthy volunteers

Not accepted

blood pressure \> 130/80 \<180/105 mmHg at the end of the wash-out
type 2 diabetes mellitus well controlled by medication and / or compliance with diet (HbA1c \<7%)
microalbuminuria in the upper range of normal (\> 200 \<300 mg/24 h)

Pregnancy, lactation or women of childbearing age
Sitting diastolic blood pressure e 105 mmHg or systolic pressure e 180 at the end of the period of wash-out
History of hypertensive encephalopathy or cerebrovascular accident within 6 months
Secondary hypertension
Heart Failure
Myocardial infarction within 6 months
Angina pectoris, clinically significant valvular disease or arrhythmia
Alteration indices of liver function or renal
Known hypersensitivity to ACE inhibitors
All other physiological or pathological condition in the opinion of the physician may affect the evaluation of the parameters under study

Aliskiren Versus Ramipril on Antiproteinuric Effect in Hypertensive, Type 2 Diabetic Patients With Microalbuminuria